CinCor is a clinical-stage biopharmaceutical company focused on developing our lead clinical candidate, baxdrostat (CIN-107), for the treatment of hypertension and other cardio-renal diseases. Baxdrostat (CIN-107) is a highly selective, oral small molecule inhibitor of aldosterone synthase, the enzyme responsible for the synthesis of aldosterone in the adrenal gland. Baxdrostat (CIN-107) has been designed to use a differentiated mechanism of action, direct inhibition of aldosterone synthase production, with the goal of providing an improved treatment for patients suffering from hypertension, or high blood pressure.

OUR PATH

We are evaluating the efficacy and safety profile of baxdrostat (CIN-107) as a potential treatment for the broader hypertensive population, including different subpopulations of hypertensive patients who have not achieved blood pressure control despite treatment. We are conducting a Phase 2 clinical trial, which we refer to as our BrigHtn trial, of baxdrostat (CIN-107) in patients whose blood pressure is not controlled despite treatment with three antihypertensive agents, including a diuretic, which is referred to as treatment resistant hypertension, or rHTN. We have recently initiated a separate Phase 2 clinical trial, which we refer to as our HALO trial, in patients with whose blood pressure is not controlled despite treatment with one or more antihypertensive agent, which is referred to as uncontrolled hypertension, or uHTN.

In addition to hypertension, we are developing CIN-107 for the treatment of primary aldosteronism, or PA, and we are exploring its utility in ameliorating complications of chronic kidney disease, or CKD. In 2021 we initiated a Phase 2 clinical trial of CIN-107 in patients with confirmed PA, which we refer to as our spark-PA trial, and, in 2022, have also initiated a Phase 2 clinical trial in patients with CKD who have uncontrolled blood pressure, which we refer to as our FigHtn-CKD trial.